A 2018 study in Dermatologic Therapy found that 38% of patients experienced rebound hyperpigmentation within 812 weeks of discontinuing hydroquinone monotherapy, likely because melanocytes compensate for reduced tyrosinase activity by upregulating MITF (microphthalmia-associated transcription factor), the master regulator of melanocyte differentiation
Ingold I, Aichler M, Yefremova E, Roveri A, Buday K, Doll S et al (2015) Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility
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The oxidized form , then, is when cysteine uses those electrons to form a covalent bond with another molecule
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