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Supplementation is often recommended during pregnancy and lactation

While B12 is generally safe, caution is needed in specific clinical situations: Lebers Disease (Hereditary Optic Neuropathy): B12 injections are generally contraindicated or should be used with extreme caution, as they may potentially aggravate optic atrophy in this rare condition

Because many degradation pathwaysincluding hydrolysisrequire the presence of water, freeze-dried peptides generally remain stable much longer than their reconstituted counterparts when stored under appropriate laboratory conditions

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