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doi: 10.1016/j.bbadis.2024.167645 52 LiGLiuCYangLFengLZhangSAnJet al

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Prx3 homodimer has a redox-sensitive cysteine that upon reaction with H 2 O 2 is oxidized to Cys-SOH, which then reacts with neighboring Cys-SH of the other subunit to form an intermolecular disulfide that can be readily reduced by thioredoxin reductase 2 (TrxRD2

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