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In the DUAL V, 40% of patients assuming Liraglutide/Degludec received 50 dose steps after 26 weeks corresponding to 1.8 mg of Liraglutide, with a wide range of variability also depending on baseline BMI (65)
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Patients with Fitzpatrick IV-VI skin should be monitored for potential irritation during initial use, particularly in combination with other actives, and formulations should be pH-controlled (pH 3.5 or lower for efficacy without excessive irritation)
The top quartile of responders exceeds these numbers by a wide margin
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