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Excessive caloric intake increases FFA load to the liver to a point that the ability of the hepatocytes to oxidize FFA or re-esterify to TG and secrete very low-density lipoproteins (VLDL) is overwhelmed

The pathway can stimulate GH release through mechanisms that are complementary to GHRH signaling, but complementary does not prove that every combination produces a superior outcome

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Annu Rev Pharmacol Toxicol 31, 25387