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Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team

After 28 days, peptide degradation accelerates and potency drops below acceptable levels

The STEP trial data in detail Understanding the clinical trial evidence gives you a realistic baseline for what to expect

Capsules offer a convenient option for those who prefer non-injection-based treatments

Error bars represent standard error