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Among the E3 ligases, MuRF1 and Atrogin-1/MAFbx are canonical atrogenes strongly upregulated during catabolic stress (e.g., denervation, fasting, glucocorticoid exposure, cancer cachexia), and are indispensable for UPS-mediated muscle degradation

Key Takeaway: Cellular health is about balance

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Without the full sequence, its impossible to reproduce the original work, a crucial form of quality-control for scientists