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The combination of these three hormones results in a weight loss effect that surpasses that achieved by individual or dual agonists, making it a cornerstone in the therapeutic approach to MASLD ( 3.3.2 Regulation of hepatic lipid metabolism Triple receptor agonists exhibit promising synergistic effects on hepatic lipid metabolism, a central pathological feature in MASLD

PMID 20628086.

Much more commonly, two copies of the second intermediary bond, forming tetraiodothyronine, also known as thyroxine (T 4 ), a thyroid hormone with four iodines

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