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IGF-1 LR3 is not appropriate for patients who are pregnant or breastfeeding, have active cancer or a cancer history (because IGF-1 stimulates cell growth broadly, including potentially malignant cells), have uncontrolled diabetes or diabetic retinopathy, or are under 21
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However, many studies involving older adults have failed to demonstrate consistent added benefits of protein supplementation, potentially due to variations in the protein dosage and RT protocol itself
In contrast, FoB exhibit lower intracellular ROS and maintain a metabolic setup that is distinct from that in MZB
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