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7), the IC 50 value of glutathione-Epothilone conjugates at 1:2 and 1:4 M/M were 1.9 and 1.45 M, respectively, compared to the control of epothilone (4.7 and 3.7 M) towards the HepG-2 cells

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These findings, therefore, implicate redox homeostasis as a central and dominant feature of ALS and suggest that regulation of the neuronal redox environment has a much broader link to neurodegeneration than previously recognized

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