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Metformin is a first-line FDA-approved medication for type 2 diabetes that reduces hepatic glucose production and improves insulin sensitivity

Copper exists in a metastable valence state, making it reactive to pH changes, antioxidants, and chelating agents

found less antioxidant activity in FF of patients with endometriosis than in control patients with tubal infertility (129, 130)

CD44 itself is transcriptionally regulated by nuclear iron, which modulates its expression through a positive feedback loop, contrary to the negative regulation of transferrin receptor by excess iron

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