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This effect of RRM1 silencing on erastin2-induced ferroptosis was specific: RRM1 silencing did not inhibit cell death in response to several mechanistically distinct small molecule inducers of apoptosis or other forms of non-apoptotic cell death that are not directly linked to intracellular GSH metabolism (Ko et al, 2019) (Fig S4A)

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Continuous drug exposure periods were defined as sequential prescription or dispensing records (dispensing records are available in all claims databases and VA) with 10,000) of patient baseline characteristics as predictors

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The resulting pellets were freeze-dried and stored at -20 C for subsequent use