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FIGURE 2 IGF SIGNALING IN THE CONTEXT OF LIGAND-RECEPTOR INTERACTIONS The IGF system is comprised of type I and type II receptors, their ligands (IGF-1 and IGF-2), IGFBPs, and IGFBP proteases ( The IGF-1 receptor is a tyrosine protein kinase consisting of two and two subunits conjoined by disulfide bridges ( IGF-1 IN EMBRYONIC AND POSTNATAL SKELETAL DEVELOPMENT CONSEQUENCES OF IGF-1 GLOBAL DEFICIENCY IGF-1 is a major anabolic signal for both embryonic and postnatal skeletal development

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