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The difference between topical and injectable is not a marginal efficiency gain

A neurologist can perform nerve conduction studies, order appropriate blood work, and potentially perform a skin biopsy to establish an objective baseline against which to measure changes

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Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site

This could impact how the body breaks down drugs and make them less effective or cause negative side effects