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This broad tissue distribution explains why GLP-1 RAs exert effects on multiple organ systems simultaneously, a property that makes them particularly suited to address the complex pathophysiology of NASH, which involves dysregulation of glucose and lipid metabolism, insulin resistance, inflammation, and fibrosis

Microdosing involves starting with a low dose and increasing to a fraction, up to 25%, of the standard maintenance dose

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It enhances insulin secretion from the pancreas, inhibits glucagon release, and promotes satiety