semaglutide Semaglutide Drug Names : Ozempic (for T2DM) - injectable Wegovy (for weight management) - injectable Rybelsus (oral) - 1st oral GLP-1 agonist (FDA approved 9/20/19) Drug Category : GLP-1 receptor agonist, hypoglycemic Synthetic peptide analog of GLP-1 Mechanism of Action: Synthetic peptide that is chemically identical to GLP-1, except for three amino acid substitutions and modifications at positions 8, 26 & 34 (Figure 1) that prevent chemical breakdown by DPP-4, and increase binding to albumin
5 weeks 10 syringes 2 per week 10 weeks 20 syringes 2 per week Round up for priming losses, dropped syringes, and site rotation
Treatment starts at 1.5mg once daily and is increased step by step, with a minimum of one month at each dose level, until the 25mg maintenance dose is reached as tolerated
For adults, take one (1) capsule daily, preferably with meals
The trade-off with MEDVi is that the lower price point sometimes translates to less intensive follow-up care