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In addition to studies on cell and mouse models, resveratrol supplementation in T2DM patients improved glycaemic control by reducing insulin resistance, which significantly alleviated chronic inflammation and oxidative stress in diabetic patients [143]
Local Actions of Melatonin in Somatic Cells of the Testis
By correlation analysis of striatal metabolites and intestinal bacteria, statistical analysis showed that Clostridium_sensu_stricto_1 was negatively correlated with metabolites on the top 20 differential gut microbiota and metabolites
These technological advancements may significantly improve the pharmacological profile of antioxidant agents and enhance their therapeutic potential in future clinical applications
Altogether, metabolomics offers a promising complement to existing biomarker strategies, supporting early diagnosis, differential classification of dementia subtypes, and possibly therapeutic stratification, provided robust algorithms and well-characterized cohorts are employed
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