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This HexaPro antigen was used in a regimen termed prime and spike, in which a priming dose was administered intramuscularly to induce peripheral immune memory and a boosting dose was administered intranasally to expand and recruit spike-specific T and B cells to the mucosa [167]

This enables once-weekly subcutaneous dosing (Ozempic for type 2 diabetes, Wegovy for obesity) or daily oral dosing (Rybelsus)

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This study uncovered that T cell-delivered granzyme A cleaves GSDMB in target cells to activate pyroptosis and antitumour immunity

AXT was studied in mouse neuronal cells (HT22) with glutamate toxicity at doses 1.255 M