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The safety and pharmacodynamic results in the multiple-dose trial must be interpreted in light of the high dose levels (2040 mg oral semaglutide) and the relatively fast initial dose escalation in this trial compared with the phase III trials, where dose levels of 314 mg oral semaglutide are investigated and a slower initial dose escalation is used to minimise gastrointestinal adverse effects
The New England journal of medicine, 391(2), 109121
Tong J, Chen Y, Ling X, Huang Z, Yao G, Xie Z
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Cautions include patients with a history of pancreatitis or severe gastrointestinal disease
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