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Ion source conditions were set as follows: spray voltage = 4 kV, sheath gas = 20 (arbitrary unit), auxiliary gas = 4 (arbitrary unit), sweep gas = 0 (arbitrary units), transfer tube temperature = 300C, RF-lens level = 50%

Judging the starting dose by the scale after one or two weeks leads to premature dose increases and unnecessary side effects

Instead, it is more appropriate to envision metabolic plasticity regarding uptake of alternative metabolic substrates and promotion of metabolic rewiring as a built-in feature that has evolved to allow cancer cells to constantly adapt to changing intracellular- and extracellular metabolic conditions 2

Participants received weekly subcutaneous injections of retatrutide at doses of 1mg, 4mg, 8mg, or 12mg, or placebo