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The FDA requires GLP-1 receptor agonists to carry a black-box warning regarding the risk of thyroid C-cell tumors, and it recommends against using them in patients with a personal or family history of medullary thyroid cell cancer or multiple endocrine neoplasia syndrome type 2a or 2b

as the first therapy to help people manage their weight and reduce cardiovascular risks, Martin Holst Lange, executive vice president and head of development at Novo Nordisk, said in a separate statement

There are many things that can go wrong, she said

Food and Drug Administration) Long-term data are limited

Compounded retatrutide from research suppliers often has shorter in-use limits because of variable formulation