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Diabetes Care (2022) 45(Suppl 1):S12543

This tiny size allows it to penetrate the skin's surface layer, the stratum corneum, more effectively than other acids

It was not until the 1950s that Jean Sterne demonstrated the effectiveness of metformin in treating diabetes in human trials for the first time (Sterne, 1963)

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This approach simplifies blood sugar control and can delay or lessen the need for insulin