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The repair signature is reminiscent of the copper signature very recently demonstrated in regulatory T cells, whose energetic and functional phenotype is highly dependent on free intracellular copper
Studies in individuals with type 2 diabetes revealed a 1.11.7 kg reduction in body weight and a 0.790.89% (8.79.78 mmol/mol) decrease in HbA 1c [34]
This confirms that the observed metabolic reprogramming was dependent on chronic activation of GLP-1R signalling and independent of its acute stimulation of insulin secretion, which may result in autocrine insulin signalling
For example, protein present in the urine would result in 1 point, and another point would be added if a new rash had appeared
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