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Yes, GLP-1 medications should be discontinued before planned conception: at least 2 months before for semaglutide, at least 1 month for tirzepatide, and when pregnancy is recognized for other agents

These findings also indicate that, at least at the central level, agonism of the GIP receptor exerts a catabolic action, suggesting that the reduction in body weight found in other studies after the administration of GIP receptor antagonists was not mediated by the brain

Cardiovascular adaptation represents another consideration for extended use

Effects of Retatrutide on Body Weight Percent change in body weight at 80 weeks (primary endpoint) showed a dose response

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