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1c), and were closely matched in participants with both survey and EHR data (median 9.45 months in EHR compared with 9.58 months in survey

None of these have been answered with rigorous human data

Strategies to minimize discomfort Follow the titration schedule The single most effective strategy is respecting the four-week intervals between dose increases

The PVN coordinates autonomic and neuroendocrine activities for regulation of metabolism, and contains pre-autonomic neurons that control pancreatic SNS activity and insulin secretion 50

doi: 10.2337/db13-0893 168 BergmannNCGasbjergLSHeimbrgerSMKroghLSLDelaFHartmannBet al