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These adaptations can support survival and resistance to selected treatments, with effects varying by cell lineage, genotype, nutrient availability, and drug mechanism (Jyotsana et al., 2022)

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The researchers on this paper speculated that thymoquinone, or TQ, the primary active constituent of [BSO], may have been primarily responsible for the effect because TQ protects cells against oxidative damage induced by a variety of free radical-generating pathologies, and it also stimulates the production of acetylcholine, which causes the release of melanin and darkening of the skin through stimulation of cholinergic receptors

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