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What the Data Actually Show | Evidence Level | Sermorelin Alone | GHK-Cu Alone | Sermorelin + GHK-Cu | |---|---|---|---| | Phase III RCT | Yes (pediatric GHD) | No | No | | Phase II RCT (adults) | Yes (Vittone 1997) | One skin-aging trial | No | | Animal studies | Multiple | Multiple | None identified | | In vitro mechanistic | Extensive | Extensive | None identified | | Case series / observational | Limited | Limited | Anecdotal only | The FDA-approved indication for sermorelin covers pediatric GH deficiency

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Growth hormones are peptides that stimulate growth, cell reproduction, and regeneration of chondrocytes and osteoblasts, as well as increase protein production and muscle mass

The MMP results in the loss of m which prevents the degradation of the voltage-sensitive PTEN-induced kinase 1 (Pink1) [272,273,274]