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The knockout of ATM can also lead to an increase in H 2 O 2 within HSCs and induce excessive proliferation and differentiation of HSCs through the activation of the p38-MAPK pathway, ultimately leading to HSC exhaustion [294]

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The safety record is generally placebo-like, but several specific findings deserve attention

Serum NO levels are suppressed by GnRH agonist and upregulated by gonadotropin stimulation during controlled ovarian stimulation in female partners from couples with male factor infertility [133]