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321,336 Altered phosphorylation of insulin receptor substrate proteins, particularly IRS-1 and IRS-2, is implicated in neuronal insulin resistance, 20,337 which impairs insulins neurotrophic effects, leading to reduced neurite outgrowth and increased vulnerability to injury
Silvagno et al., 2020
In fact, bupropion is one of the only antidepressants associated with modest weight loss rather than weight gain, which is precisely why so many people taking it become interested in tirzepatide weight loss protocols in the first place
7 If you want to put the levers in order of importance for protecting body composition on a GLP-1: resistance training first, a protein target around 1.6 g/kg of target body weight second (see our protein recommendations and consider Whey Rx if hitting the target on a suppressed appetite is the bottleneck), sleep third, and creatine somewhere after that
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