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Methylcobalamin is used to treat pernicious anemia and vitamin B12 deficiency, as well as to determine vitamin B12 absorption in the Schilling test
5-Amino-1MQ targets NNMT, an enzyme that consumes S-adenosylmethionine (SAM), the cell's principal methyl donor
Traditional swallowed forms have limited effectiveness due to digestive breakdown, but sublingual troches and liposomal formulations improve absorption significantly
High doses can be safe with proper monitoring of **liver values, blood glucose/HbA1c, and uric acid**, but are not suitable for everyone
All three are correctable in two minutes during a supervised session and take weeks to self-correct through trial and error
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