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(Hongjingtian), and it has been reported that chemical components salidroside can coordinate metabolic reprogramming by modulating the HIF-1 signaling pathway in AMS ( Our teams previous study found that polysaccharide extracted from Potentilla anserina L could inhibit oxidative stress and inflammatory responses to treat and prevent HACE and HAPE, and its mechanism of action may be to block the activation of the NF-B and HIF-1 signaling pathways, which inhibits the production of downstream pro-inflammatory cytokines (IL-1, IL-6, TNF-, and VEGF) (Pan et al., 2020

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Moller N, Jorgensen JO

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