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In line with this, Campos et al

First, activation of GLP-1 receptors in the gastrointestinal tract causes delayed gastric emptying, meaning food remains in the stomach longer than normal

doi: 10.2174/092986712802002572

The skin acts as a reservoir, allowing the peptide to remain active in the local tissue for many hours, creating a prolonged local effect instead of a short systemic one

J Mol Histol