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For example, in a previous study, teneligliptin ameliorated hypertension and comorbid cardiac remodeling in SHR by attenuating circulating AngII (93)
Rapamycin, an mTOR inhibitor, similarly promotes autophagy, attenuates pathological remodeling and is now in phase II clinical trials for HFpEF (Tables 1 and 2)
Take Away Excess melanin production can lead to hyperpigmentation, causing certain areas of the skin to appear darker
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