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Orthogonal analytical workflows help confirm structural identity and improve regulatory confidence

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While the top of TM6 and ECL3 could not be confidently modelled for the exendin-4 complex, the portion of TM6 and TM7 that were modelled, along with the weak density corresponding to ECL3 supports a backbone conformation more similar to GLP-1 and oxyntomodulin bound receptors, rather than exendin-P5, albeit it is likely that this region is more conformationally dynamic

The discovery of robust predictors of treatment response could enable the prediction, from the outset, of a persons probable treatment journey, and thereby pave the way for precision medicine through the clinical implementation of combined phenotypic and genotypic prediction models