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While true pharmacological tolerance to GLP-1 receptor agonists is not well-established, tachyphylaxis of the gastric emptying effect has been documented with GLP-1 receptor agonists
K.SimeoneT
In the human trial, the design was simpler still: 55 participants with obesity were randomized to receive either Tirzepatide or a placebo for 18 weeks
Sublingual Delivery: Convenience and Compliance Advantages Sublingual tirzepatide eliminates the needle anxiety and injection technique requirements that some patients find burdensome
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