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Additional studies demonstrated that SREBP-1c -/- mice had impaired induction of hepatic genes coding for fatty acid biosynthesis (e.g., acetyl-CoA carboxylase, fatty acid synthase, and stearoyl-CoA desaturase) compared to wild type mice [17]

For instance, the rectal administration of taurocholic acid increased GLP-1 secretion in both healthy subjects [177] and obese type 2 diabetic volunteers [178]

However, the obesogenic effects of GIP are only apparent during nutrient excess, as chow-fed Gipr and Gip knockout animals are of similar weight as their wild type counterparts (69)

The hybridisation probes used in this study were generated by PCR using primers ogliA1 and ogliA2 for AFUA_6G09710, ogliG7 and ogliG8 for AFUA_6G09690, ogliT7 and ogliT8 for AFUA_6G09740, and ogliZ1 and ogliZ2 for AFUA_6G09630