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As you age, collagen production slows down and your skin begins to lose its structure

While the liver has substantial storage capacity, supraphysiological doses (such as from injections) are largely excreted in the urine

Existing Active Breakouts: If your acne is currently active, vitamin B12 may worsen the condition in some cases

- Liver enzymes if any preexisting liver concern, given the monkey toxicology signal

[3] If you require B12 supplementation and are concerned about skin effects, discuss preventive skincare strategies with your healthcare provider before starting treatment, and monitor your skin during the initial weeks of therapy