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Trinh and Farrer, 2013), mitochondrial dysfunction, neuroinflammation and environmental factors are increasingly appreciated as key determinants of dopaminergic neuronal susceptibility in PD, and are a feature of both familial and sporadic forms of the disease (Ryan et al., 2015)

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These include vitamin B 12 deficiency, mutations of the MTHFR gene, and epigenetic modifications that alter expression of other key enzymes involved in folate metabolism