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For both of these final limitations, the use of rich multimodal clinical data such as clinical notes to assess patient-level features driving motivation for GLP-1 use and discontinuation, as well as imaging to quantify and assess fat loss through CT scans could help shed light on the true impact of GLP-1s on body composition as well as patient profiles that are related to varying levels of treatment effect
Bruising and its effect on absorption Bruising at the injection site is mostly cosmetic, but large bruises can trap medication in the tissue, slowing absorption
For the early weeks or a sensitive gut: PHGG Partially hydrolysed guar gum (PHGG) is the gentler choice, and on a slowed semaglutide gut gentle is a real advantage
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Lancet 2009;374:1606-1616 Erratum in: Lancet 2010;375:984
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