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In this regard, we include three clinical studies published from 2021 to 2023 based on the inclusion criteria that examined oral curcumin supplementation, primarily in women who were 30 to over 60 years of age (Table 2)

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Clin Endocrinol (Oxf) 2014;80(3):425-31

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Open questions include tissue-selective delivery, chronic dosing effects on one-carbon metabolism, and interactions with NAD precursor strategies [14,8,9]

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