Current NHS eligibility criteria for semaglutide 2.4 mg (Wegovy) for weight management, according to NICE TA875, include: Body Mass Index (BMI) 35 kg/m with at least one weight-related comorbidity (such as type 2 diabetes, hypertension, dyslipidaemia, obstructive sleep apnoea) For people from certain high-risk ethnic groups (such as South Asian, Chinese, Black African, or African-Caribbean), lower BMI thresholds apply (typically reduced by 2.5 kg/m) Treatment must be prescribed within specialist weight management services only Treatment is limited to a maximum duration of 2 years Must be used as an adjunct to a reduced-calorie diet and increased physical activity Liraglutide 3 mg (Saxenda) availability varies significantly across NHS regions and is not routinely commissioned in many areas
Main body: We present a structured, fertility-centered, hypothesis-generating narrative synthesis of the metabolicreproductivepregnancy continuum in PCOS, integrating evidence from randomized trials, observational studies, reviews, and clinical guidance
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Depriving tumours of extracellular glutathione or inhibiting its breakdown is potentially a viable therapeutic strategy for cancer patients, the authors state
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