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The nine compounds in this category span a structural range: peptide single agonists (semaglutide, liraglutide), peptide dual agonists (tirzepatide for GIP/GLP-1
In addition to glucose control, emerging evidence suggests semaglutide may exert anti-inflammatory effects and improve vascular health by reducing inflammatory cytokines
Additionally, experimental techniques based on targets and phenotypes, along with in silico resources like virtual high-throughput screening (HTS) and ligand- and structure-based molecular modeling, have become increasingly accessible for identifying candidates for repurposing (Wadood et al., 2013
By avoiding the limitations of oral intake such as low bioavailability and digestive breakdown
