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The partial rescue of the above-described symptomatology can be ascribed to the activity of other transporters such as ATB 0,+ (SLC6A14), MCT9, and probably, OCTN1 (SLC22A4) that accept carnitine with a much lower affinity if compared to OCTN2
6.2 Inflammation and immune cell activation Hyperglycemia directly promotes inflammatory gene expression and activates immune cells via multiple pathways, amplifying inflammatory mediator production and impairing vascular endothelial cell structural and functional integrity (68)
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