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References AL-Mhanna SB, Batrakoulis A, Wan Ghazali WS, et al

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Eligible studies comprised original research articles with full-text availability, clinical trials evaluating antioxidant interventions, and those comparing such interventions with conventional pharmacological treatments or untreated control groups

Given that CoQH2 serves as an alternative anti-ferroptosis system operating in parallel with GPX4, the differential metabolic environments between malignant and normal cells likely contribute to the divergent effects of lactate on ferroptosis sensitivity observed across these cellular contexts