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As a vegetarian, I have to supplement B12 as I tend to be low, so that was an added bonus to the shot

Cobalamin separates from the protein during digestion, and a substance called intrinsic factor binds to cobalamin for the body to absorb it into the blood

There are practical reasons too: B can be unstable if mixed with certain other vitamins in solution, and dosing schedules for B deficiency (pernicious anemia, for instance) may differ

Not everyone does, but labs can be helpful especially if fatigue or suspected deficiencies are part of the story

While side effects are rare, some individuals may experience mild discomfort at the injection site or temporary symptoms such as dizziness or nausea