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Sci Rep 14:19822

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CPP-CAND disrupts FOXO4-p53 foci and induces apoptosis through caspase-dependent pathways FOXO4 is progressively recruited to euchromatin foci following senescence induction and is retained in the nucleus of senescent cells through its interaction with p53, contributing to the maintenance of the senescent state 34

Few more studies have suggested that other proteins, such as p21 or p62, also restrict the Keap1Nrf2 interaction and induce Nrf2-associated drug resistance in tumor cells (Chen et al., 2009

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