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This allows time for the compound and its metabolites to be eliminated from the system
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We dont have large randomized trials that look at long term safety, live birth, and health of offspring
No pharmaceutical company, no academic medical center, and no government agency has found the existing preclinical data compelling enough to fund a rigorous human trial in over 30 years
Safety studies have evaluated single doses up to 0.4 grams per kilogram of body weight (approximately 28 grams for a 70-kilogram adult) without serious adverse effects, though gastrointestinal symptoms represent the primary tolerability concern
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