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The decrease in visceral adipose tissue was sustained over 52 weeks
Research demonstrates that acetyl-L-carnitine ameliorates insulin resistance through multiple mechanisms: restoring tissue carnitine levels in skeletal muscle and myocardium, improving mitochondrial -oxidation of fatty acids to reduce accumulation of lipotoxic intermediates, enhancing glucose disposal and oxidation capacity, and reducing inflammatory signaling that impairs insulin receptor function
JAMA 277 , 14391444 (1997)
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