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These results provide evidence that HsaGSTA3-3, and also HsaGST A1-1, catalyze steroid isomerization in coordination with HSD3B2 to produce progesterone and 4-androstenedione from their delta5-precursors pregnenolone and dehydroepiandrosterone in steroidogenic cells

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Crucially, experimental interventions targeting FAO modulate this injury: Enhancing FAO with L-carnitine reduced hyperoxia-induced impairments in alveolarization and vascularization, whereas inhibiting FAO exacerbated these injuries