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The efficacy and safety of tirzepatide, with a special focus on cardiovascular safety, were investigated in the 52-week SURPASS-4 trial testing tirzepatide versus insulin glargine in adults with T2D and a high cardiovascular risk under inadequate glycemic control at baseline on one to three oral glucose-lowering medications (metformin, sulfonylurea, SGLT-2 inhibitor) (74)
Lilly will have to establish that it can manufacture retatrutide consistently and satisfy FDA requirements for identity, purity, potency, stability, and quality
If you are looking for a treatment for a person, this is not that, and a pharmacy or GP is the right door
This substantial reduction helps many patients achieve NICE-recommended glycaemic targets whilst also supporting weight loss and cardiovascular health
The thousands of anecdotal human reports suggest similar effects to animal studies, but formal human clinical trials remain lacking
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